Arabinogalactan, particularly in its larch form, is a high-molecular-weight polysaccharide that serves as a proteoglycan composed of d-galactose and l-arabinose. Its immune-enhancing properties are attributed to its ability to stimulate the production of short-chain fatty acids (SCFAs), notably butyrate and propionate. Clinical studies indicate that larch arabinogalactan enhances the activity of natural killer cells and macrophages while influencing pro-inflammatory cytokine secretion. Furthermore, it has been shown to reduce the incidence of cold infections by 23% and modulate immune responses during vaccination, suggesting a role in both B-cell and T-cell mediated immunity. Additionally, arabinogalactan promotes favorable shifts in the gut microbiome, decreasing Firmicutes and enhancing Bacteroidetes and Bifidobacterium levels, which may also contribute to its effects on metabolic functions and gastrointestinal health.

Mechanisms of Action and Benefits:

• Immune Support: Enhances the body's defense mechanisms against infections, particularly respiratory illnesses.
• Gut Health: Modulates the gut microbiome, promoting beneficial bacteria and reducing harmful byproducts.
• Short-Chain Fatty Acid Production: Increases levels of SCFAs, which are crucial for gut health and immune function.
• Digestive Health: Alleviates constipation by fostering a healthy microbial environment.

References:

1. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond). 2016;13:28. Link
2. Chen O, Sudakaran S, Blonquist T, Mah E, Durkee S, Bellamine A. Effect of arabinogalactan on the gut microbiome: A randomized, double-blind, placebo-controlled, crossover trial in healthy adults. Nutrition. 2021;90:111273. Link